Chapron D J, Cameron I R, White L B, Merrall P
J Am Geriatr Soc. 1982 Oct;30(10):651-5. doi: 10.1111/j.1532-5415.1982.tb05064.x.
The disposition kinetics of lithium were studied in six elderly women who had been maintained on this medication for several years. Lithium administration was stopped abruptly. Plasma, whole blood, and erythrocyte half-lives were then measured, as well as renal plasma clearance and distribution volume. Half-life values in whole blood and in its components were found to be similar. The plasma lithium half-life approximated that in younger schizophrenics, but appeared prolonged when compared with half-lives reported for young normal volunteers. Renal plasma clearance and distribution volume of lithium appeared substantially reduced when compared with published values. The data are consistent with altered lithium disposition in the aged.
在六名服用锂剂数年的老年女性中研究了锂的处置动力学。突然停止给予锂剂。随后测量了血浆、全血和红细胞半衰期，以及肾血浆清除率和分布容积。发现全血及其成分中的半衰期值相似。血浆锂半衰期接近年轻精神分裂症患者，但与年轻正常志愿者报告的半衰期相比似乎延长。与已发表的值相比，锂的肾血浆清除率和分布容积似乎大幅降低。这些数据与老年人锂处置的改变一致。
