Tani M, Murayama A, Ohnishi S, Ogawa S, Handa S, Nakamura Y, Maehara M, Soma Y, Inoue T
J Cardiogr. 1982 Mar;12(1):11-22.
In order to identify the determinants for surgical procedures in mitral stenosis, we evaluated two-dimensional echocardiographic findings of the mitral valve and subvalvular structures in 35 patients undergoing open mitral commissurotomy (OMC) or valve replacement (MVR). As indices of a degree of subvalvular shortening and valvular flexibility, the distance between the mitral ring and the tip of the anterior mitral leaflet was measured by the LV long-axis view by in both midsystole (S) and early diastole (D). As a possible major determinant for MVR, a degree of valvular calcification (C) was semi-quantatively scored according to the extent of abnormally strong echo density. In nine of 11 patients undergoing MVR, a main reason for selecting MVR was a marked thickening or shortening of subvalvular structures. In patients in whom OMC was feasible, the degree of improvement of the mitral valve area (delta MVA) was assessed by the pre- and post-operative mitral valve areas (MVA) measured on the LV short-axis view, which were averaged 0.15 and 1.38 cm2, respectively.
The index C was significantly higher in cases with MVR than those with OMC (9.2 +/- 2.6 vs 4.7 +/- 2.3 points, p less than 0.001), although there was a significant overlap between these two groups and index C did not correlate with delta MVA in the OMC patients. Similarly, the value S was significantly smaller in patients undergoing MVR than those undergoing OMC (1.2 +/- 0.4 vs 0.7 +/- 0.2 cm, p less than 0.001), though S did not correlate with delta MVA. On the other hand, the index of valve flexibility D--S was smaller in patients undergoing MVR (0.5 +/- 0.3 vs 0.8 +/- 0.3 cm, p less than 0.05) and correlated well with delta MVA (delta MVA = 0.699 x (D--S)+0.007, R = 0.678, p less than 0.02) in patients undergoing OMC. Furthermore, in all patients undergoing OMC with D--S greater than or equal to 0.8 cm, delta MVA was above 0.5 cm2, contrasting with delta MVA of 0.5 cm2 or less in 6 of 7 patients with D--S less than 0.7 cm. Using these indices, surgical procedures were successfully predicted in another 7 prospectively studied patients and predicted delta MVA in 4 patients was quite comparable with actual delta MVA. It was concluded that measurements of S and D by two-dimensional echocardiography are useful, 1) to predict patients requiring MVR and 2) to predict patients with inadequate delta MVA in whom OMC is surgically feasible.
为了确定二尖瓣狭窄手术方式的决定因素,我们评估了35例行二尖瓣直视交界切开术(OMC)或瓣膜置换术(MVR)患者的二尖瓣及瓣下结构的二维超声心动图表现。作为瓣下缩短程度和瓣膜柔韧性的指标,在左室长轴切面于收缩中期(S)和舒张早期(D)测量二尖瓣环与二尖瓣前叶尖端之间的距离。作为MVR可能的主要决定因素,根据异常强回声密度的范围对瓣膜钙化程度(C)进行半定量评分。在11例行MVR的患者中,有9例选择MVR的主要原因是瓣下结构明显增厚或缩短。对于可行OMC的患者,通过左室短轴切面测量术前和术后二尖瓣面积(MVA)来评估二尖瓣面积改善程度(ΔMVA),术前和术后平均MVA分别为0.15和1.38 cm²。
MVR患者的指标C显著高于OMC患者(9.2±2.6对4.7±2.3分,p<0.001),尽管两组之间有明显重叠,且OMC患者中指标C与ΔMVA无关。同样,MVR患者的S值显著小于OMC患者(1.2±0.4对0.7±0.2 cm,p<0.001),尽管S与ΔMVA无关。另一方面,MVR患者的瓣膜柔韧性指标D - S较小(0.5±0.3对0.8±0.3 cm,p<0.05),且在OMC患者中与ΔMVA相关性良好(ΔMVA = 0.699×(D - S)+0.007,R = 0.678,p<0.02)。此外,所有D - S≥0.8 cm的OMC患者,ΔMVA均高于0.5 cm²,而7例D - S<0.7 cm的患者中有6例ΔMVA为0.5 cm²或更小。利用这些指标,在另外7例前瞻性研究患者中成功预测了手术方式,4例患者预测的ΔMVA与实际ΔMVA相当。结论是,二维超声心动图测量S和D有助于:1)预测需要MVR的患者;2)预测OMC手术可行但ΔMVA不足的患者。