De Bono A M, Pillers E M
J Epidemiol Community Health (1978). 1978 Sep;32(3):178-82. doi: 10.1136/jech.32.3.178.
A study was made of the clinical stage at presentation in 10 081 cases of carcinoma of the breast registered with the East Anglian Cancer Registration Bureau between 1960 and 1975. Information about the length of clinical history was obtained in 8862 cases. There has been a gradual increase in the population-adjusted incidence of breast carcinoma in the region during the period studied. Since 1968, there has been a consistent increase in Stage I and II registrations, but a fall in Stage III registrations. Stage IV registrations have remained constant. A greater proportion of women with Stage I or II lesions present with a short clinical history, and this pattern has not changed during the course of the study. We suggest that increased interest in, and opportunities for, the early diagnosis of breast disease are leading to a change in the pattern of presentation.
对1960年至1975年间在东安格利亚癌症登记局登记的10081例乳腺癌病例的就诊时临床分期进行了研究。在8862例病例中获取了有关临床病史时长的信息。在所研究期间，该地区经人口调整后的乳腺癌发病率呈逐渐上升趋势。自1968年以来，I期和II期登记病例持续增加，而III期登记病例有所下降。IV期登记病例保持稳定。I期或II期病变的女性患者中，有更大比例的人临床病史较短，且在研究过程中这种模式并未改变。我们认为，对乳腺疾病早期诊断的关注度提高以及诊断机会增加，正在导致就诊模式发生变化。
