Sarne Y, Weissman B A, Urca G
J Neurochem. 1982 Nov;39(5):1478-80. doi: 10.1111/j.1471-4159.1982.tb12594.x.
Electroconvulsive shock (ECS) administrations repeated for 10 consecutive days cause an elevation in the opioid content of the rat brain. Two different endogenous opioids, enkephalin and humoral-endorphin, undergo independent changes that differ in both their time course and intracerebral localization. These metabolic changes parallel long-term behavioral modifications such as the development and dissipation of tolerance to the analgesic effect of ECS. The activation of two different, independent, endogenous opioid systems by ECS is in agreement with previous behavioral and pharmacological studies.
连续10天重复给予电惊厥休克（ECS）可导致大鼠脑内阿片类物质含量升高。两种不同的内源性阿片类物质，脑啡肽和体液内啡肽，经历独立的变化，其时间进程和脑内定位均有所不同。这些代谢变化与长期行为改变平行，如对ECS镇痛作用耐受性的产生和消退。ECS激活两种不同、独立的内源性阿片系统，这与先前的行为学和药理学研究结果一致。
