Bayon A, Shoemaker W J, Bloom F E, Mauss A, Guillemin R
Brain Res. 1979 Dec 21;179(1):93-101. doi: 10.1016/0006-8993(79)90493-1.
Radioimmunoassay and microdissection procedures were used to study the perinatal development of the endorphin- and enkephalin-containing systems in the rat brain. In contrast to values reported on adult rat, endorphin levels are much higher than enkephalin levels on embryonic day 16. The highest endorphin values are found in the diencephalon, midline telencephalon and medulla-midbrain regions. Perinatally, enkephalin content increases at a faster rate than endorphin in all brain regions, producing a marked drop of the endorphin/enkephalin ratios. Between postnatal days 6 and 25, both endorphin and enkephalin levels increase, approaching their adult distribution pattern. No correlation was found between regional distributions or rates of increase of endorphin and enkephalin in any of these developmental stages, suggesting that the two peptide systems develop independently from each other.
采用放射免疫分析法和显微解剖法研究大鼠脑内含内啡肽和脑啡肽系统的围产期发育。与成年大鼠的报道值相反，胚胎第16天时内啡肽水平远高于脑啡肽水平。内啡肽的最高值出现在间脑、终脑中线和延髓 - 中脑区域。在围产期，所有脑区中脑啡肽含量的增加速度比内啡肽快，导致内啡肽/脑啡肽比值显著下降。在出生后第6天至25天之间，内啡肽和脑啡肽水平均升高，接近其成年分布模式。在这些发育阶段的任何一个阶段，均未发现内啡肽和脑啡肽的区域分布或增加速率之间存在相关性，这表明这两个肽系统彼此独立发育。
