Blum M
J Gynecol Obstet Biol Reprod (Paris). 1978 May-Jun;7(4):789-92.
Knowing that examining the levels of aminopeptidases in the serum of pregnant women can give us information about normal feto-placental function, we have tried to see if testing for these enzymes in urine of women with normal pregnancies could lead us to a more adequate and easy screening for fetal distress. With this end in view we examined the activity of urinary cystine aminopeptidase (CAP) in a group of 60 pregnant women at different stages of normal pregnancies. This activity was determined on 24 hour specimens of urine collected at different times in pregnancy and the results showed that there were variations from one week to another. As compared with activity in serum in normal pregnancies, urinary activity of this enzyme is raised in the first trimester of the pregnancy and lowered in the last trimester. The explanation of other authors about the possibility of these enzymes with high molecular weights passing into the urine is discussed. Asymptomatic bacteriuria is common in pregnancy, and so it can explain how CAP is excreted in the urine. But this hypothesis has still to be studied and proven.
鉴于检测孕妇血清中的氨肽酶水平能为我们提供有关正常胎儿 - 胎盘功能的信息，我们试图探究对正常妊娠女性尿液中的这些酶进行检测，是否能让我们对胎儿窘迫进行更充分且简便的筛查。出于这一目的，我们检测了60名处于正常妊娠不同阶段的孕妇尿液中胱氨酸氨肽酶（CAP）的活性。该活性是在孕期不同时间收集的24小时尿液样本上测定的，结果显示每周都有变化。与正常妊娠血清中的活性相比，这种酶的尿液活性在妊娠早期升高，在妊娠晚期降低。本文讨论了其他作者关于这些高分子量酶进入尿液可能性的解释。无症状菌尿在孕期很常见，因此它可以解释CAP是如何在尿液中排泄的。但这一假设仍有待研究和证实。
