Artner J, Baumung H, Ogris E
Wien Klin Wochenschr. 1977 Aug 12;89(15):524-31.
Serial determinations of serum HPL and HCG levels were carried out in 68 diabetic women during the whole course of pregnancy. In diabetic pregnancies of the type B--D according to White's classification, HPL levels were significantly lower than control values from the 10th to the 22nd week. In diabetic pregnancies of the type White A, HPL levels were significantly lower than the normal controls at the 10th and the 38th week, otherwise there was no significant difference between the two groups. A decrease in HPL level occurred in the 37th week in normal pregnancies and in the 34th week in diabetics. Integrated values of HPL over each trimester of pregnancy (which give a measure of the overall hormone production), were all significantly lower in the diabetic pregnancies than in the normal controls. Peak levels of HCG were found from the 8th to 12th week in normal pregnancy; subsequently a continuous fall was observed until the end of pregnancy. HCG levels were significantly higher in diabetic than normal pregnancies following the 30th week and generally rose to the end of pregnancy. The integral HCG values, in diabetics of all White groups, were significantly lower in the first trimester and significantly higher in the third trimester than in the normal controls. There was no difference in integral hormone production between diabetics and controls in the second trimester. A sudden drop in the level of both hormones is a signal of fetal distress.
对68例糖尿病孕妇在整个孕期进行了血清人胎盘催乳素（HPL）和人绒毛膜促性腺激素（HCG）水平的连续测定。根据怀特分类法，B - D型糖尿病妊娠中，从第10周到第22周，HPL水平显著低于对照值。在怀特A型糖尿病妊娠中，第10周和第38周时HPL水平显著低于正常对照，否则两组之间无显著差异。正常妊娠中HPL水平在第37周下降，糖尿病孕妇在第34周下降。妊娠各期HPL的综合值（可衡量总体激素产生情况），糖尿病妊娠均显著低于正常对照。正常妊娠中HCG峰值出现在第8周到第12周；随后观察到持续下降直至妊娠结束。糖尿病孕妇在第30周后HCG水平显著高于正常妊娠，且一般持续上升至妊娠结束。所有怀特组糖尿病孕妇的HCG综合值，在孕早期显著低于正常对照，在孕晚期显著高于正常对照。糖尿病孕妇与对照在孕中期的激素产生综合值无差异。两种激素水平突然下降是胎儿窘迫的信号。
