Wallner S F, Vautrin R M, Buerk C, Robinson W A, Peterson V M
J Trauma. 1982 Sep;22(9):774-80. doi: 10.1097/00005373-198209000-00010.
Anemia is invariably seen in patients who have been severely burned, and a number of factors have been implicated in its etiology. Prior studies have suggested that a depressed rate of erythropoiesis is involved. In order to study this, we evaluated the effect of serum from burned patients on red cell and white cell colony growth in vitro. We found that these sera were capable of inhibiting red cell, but not white cell, colony growth. Additional experiments indicated that this was related to the presence of some substance in the burned serum rather than the absence of a factor required for colony formation. Further studies, including review of clinical data, suggested that this effect was not due to topical medications nor to episodes of bacterial sepsis. Serial studies showed that inhibition was often not present in the immediate postburn period but developed gradually, reaching maximum intensity approximately 20 to 30 days following the burn and then returning toward normal as patients healed their injury. Our studies permit the hypothesis that inhibition of erythropoiesis plays a role in the pathogenesis of the anemia of thermal injury.
严重烧伤患者总会出现贫血症状，其病因涉及多种因素。先前的研究表明，红细胞生成率降低与之有关。为了对此进行研究，我们评估了烧伤患者血清对体外红细胞和白细胞集落生长的影响。我们发现，这些血清能够抑制红细胞集落生长，但不能抑制白细胞集落生长。进一步的实验表明，这与烧伤血清中某种物质的存在有关，而非集落形成所需因子的缺乏。包括临床数据回顾在内的进一步研究表明，这种作用并非由于局部用药或细菌性败血症发作所致。系列研究显示，抑制作用在烧伤后即刻通常并不存在，而是逐渐出现，在烧伤后约20至30天达到最大强度，然后随着患者伤口愈合而恢复正常。我们的研究支持这样一种假说，即红细胞生成受抑制在热损伤贫血的发病机制中起作用。
