Stazhadze L L, Demidova T M, Kudriashova Zh M, Repenkova L G
Kosm Biol Aviakosm Med. 1982 Jul-Aug;16(4):20-4.
The effect of intravenous injections of 20% mannitol in a dose of 1 g per kg of body weight at a rate of 5 ml/min on the central circulation and cardiac contractile function was investigated. The infusions were performed to 18 healthy male volunteers, who participated in a head-down tilt test at -8 degrees, during the control period, on days 3, 7 and 14 of bed rest, and during the recovery. It was found that the prolonged osmo-therapy produced a clinically distinct dehydration effect without influencing central circulation. The therapy also led to positive cardiodynamics which was indicative of a decrease of the heart unproductive work and an improvement of left ventricle contractile function.
研究了以5毫升/分钟的速度静脉注射剂量为1克/千克体重的20%甘露醇对中心循环和心脏收缩功能的影响。对18名健康男性志愿者进行输注，他们在对照期、卧床休息第3天、第7天和第14天以及恢复期间参加了-8度头低位倾斜试验。结果发现，延长的渗透疗法产生了明显的临床脱水效果，而不影响中心循环。该疗法还导致了积极的心脏动力学变化，这表明心脏无效功减少，左心室收缩功能得到改善。
