检测抑制胃溃疡形成的药物。
Testing for drugs inhibiting the formation of gastric ulcers.
作者信息
West G B
出版信息
J Pharmacol Methods. 1982 Aug;8(1):33-7. doi: 10.1016/0160-5402(82)90005-5.
PMID:7121015
Abstract
Copper salicylate has been shown to be an inhibitor of gastric lesions in rats induced by aspirin, indomethacin and cold stress whereas cimetidine was only effective against those produced by cold stress. The results are in line with those reported earlier for the anti-ulcer activity of sodium salicylate and metiamide respectively. On this basis, it appears that the animal model of stress-induced gastric lesions in the rat is the most suitable for testing the activity of new-antiulcer drugs.
摘要
水杨酸铜已被证明是大鼠中由阿司匹林、吲哚美辛和冷应激诱导的胃部损伤的抑制剂，而西咪替丁仅对冷应激产生的损伤有效。这些结果与先前分别报道的水杨酸钠和甲硫米特的抗溃疡活性结果一致。在此基础上，似乎大鼠应激性胃损伤的动物模型最适合用于测试新型抗溃疡药物的活性。
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