Wu K M, Martin W R
Life Sci. 1982 Jul 12;31(2):151-7. doi: 10.1016/0024-3205(82)90427-1.
Cardiovascular, respiratory and analgesic effects of fentanyl and naloxone were studied in normotensive acutely decerebrated dogs. Naloxone (1 mg/kg, i.v.) increased skin twitch reflex latency, mean blood pressure, pulse pressure, respiratory rate and minute volume. Fentanyl (50 micrograms/kg, i.v.) decreased heart rate and blood pressure while the animals were artificially ventilated. The skin twitch reflex latency was not significantly altered. Nine minutes later, naloxone (1 mg/kg, i.v.) was administered and the fentanyl-induced cardiovascular depression was reversed above the control level. The skin twitch reflex latency remained unchanged. These findings give further evidence that the endogenous opioid system plays an important role in the brainstem control of circulation and respiration. The mechanism of the anomalous analgesic response of the acutely decerebrated dog requires further investigation.
在血压正常的急性去脑犬中研究了芬太尼和纳洛酮对心血管、呼吸及镇痛的作用。纳洛酮（静脉注射1毫克/千克）可增加皮肤抽搐反射潜伏期、平均血压、脉压、呼吸频率和每分通气量。在动物进行人工通气时，芬太尼（静脉注射50微克/千克）可降低心率和血压。皮肤抽搐反射潜伏期无显著改变。九分钟后，静脉注射纳洛酮（1毫克/千克），芬太尼引起的心血管抑制被逆转至高于对照水平。皮肤抽搐反射潜伏期保持不变。这些发现进一步证明内源性阿片系统在脑干对循环和呼吸的控制中起重要作用。急性去脑犬异常镇痛反应的机制需要进一步研究。
