von Lilienfeld-Toal H, Gerlach I, Klehr H U, Issa S, Keck E
Nephron. 1982;31(2):116-22. doi: 10.1159/000182629.
Immunoreactive parathyroid hormone (iPTH) was measured in the serum of 20 patients with early renal failure (ERF) using three assays with different specificity. Half of these patients had elevated iPTH in one or more assays, up to twice the upper limit of normal. In contrast, 36 patients with a creatinine clearance below less than 20 ml/min had an 80% elevated iPTH, up to 5 times the upper limit of normal. The patients with ERF and elevated iPTH had a lower serum calcium but no higher serum phosphate than those with normal iPTH. The differences in iPTH in early and end-stage renal failure can be explained by known differences in metabolism of different PTH forms in uremia.
采用三种特异性不同的检测方法，对20例早期肾衰竭（ERF）患者的血清进行免疫反应性甲状旁腺激素（iPTH）检测。这些患者中有一半在一种或多种检测中iPTH升高，最高可达正常上限的两倍。相比之下，36例肌酐清除率低于20 ml/min的患者中，80%的患者iPTH升高，最高可达正常上限的5倍。与iPTH正常的患者相比，ERF且iPTH升高的患者血清钙较低，但血清磷酸盐不高。早期和终末期肾衰竭患者iPTH的差异可通过已知的尿毒症中不同PTH形式代谢差异来解释。
