Hawker C D, Di Bella F P
Contrib Nephrol. 1980;20:21-37. doi: 10.1159/000384951.
Two assays for immunoreactive parathyroid hormone (iPTH) with different specificities were used to evaluate the role of iPTH measurement in patients with chronic renal failure (CRF). One measured largely C-terminal iPTH fragments, the other largely intact iPTH. In untreated CRF, the log iPRH for each assay was significantly correlated with the reciprocal of the creatinine clearance (CCr). C-terminal iPTH was elevated at relatively high CCr values, but intact iPTH was not elevated until later in the progression of CRF. In hemodialysis patients treated with 25-hydroxyvitamin D3, intct iPTH correlated better than C-terminal iPTH with clinical improvement. These two assays used together were more helpful in evaluation of CRF patients than either assay alone.
采用两种具有不同特异性的免疫反应性甲状旁腺激素（iPTH）检测方法，以评估iPTH检测在慢性肾衰竭（CRF）患者中的作用。一种主要检测C端iPTH片段，另一种主要检测完整的iPTH。在未经治疗的CRF患者中，每种检测方法的iPRH对数与肌酐清除率（CCr）的倒数显著相关。C端iPTH在相对较高的CCr值时升高，但完整的iPTH直到CRF进展后期才升高。在接受25-羟维生素D3治疗的血液透析患者中，完整的iPTH与临床改善的相关性优于C端iPTH。这两种检测方法联合使用比单独使用任何一种检测方法对CRF患者的评估更有帮助。
