Mulder H, Silberbusch J, Hackeng W H, Koorevaar G, den Ottolander G J
Nephron. 1982;31(2):123-8. doi: 10.1159/000182630.
In 27 patients with end-stage chronic renal failure an elevated calcitonin (CT) and parathyroid hormone was found. On stimulation with Ca i.v. there were 9 cases in whom delta CT proved to be higher than the maximal response of 50 pg ml-1 in controls. Supranormal CT responses were found predominantly in patients with normal alkaline phosphatase, who as a group increased their CT from 94.5 +/- 61 to 142.0 +/- 94 pg ml-1 (p less than 0.02). In contrast to this, patients with elevated alkaline phosphatase who also had a higher level of parathyroid hormone maintained unchanged CT on Ca stimulation. It is concluded that in chronic renal failure with severe secondary hyperparathyroidism, delta CT on stimulation is normal, while an enhanced delta CT often exists when hyperparathyroidism is of insufficient degree to cause a raised alkaline phosphatase.
在27例终末期慢性肾衰竭患者中，发现降钙素（CT）和甲状旁腺激素水平升高。静脉注射钙剂刺激后，有9例患者的ΔCT高于对照组最大反应值50 pg/ml。超正常CT反应主要见于碱性磷酸酶正常的患者，该组患者的CT从94.5±61 pg/ml增至142.0±94 pg/ml（p<0.02）。与此相反，碱性磷酸酶升高且甲状旁腺激素水平也较高的患者在钙剂刺激后CT保持不变。结论是，在严重继发性甲状旁腺功能亢进的慢性肾衰竭中，刺激后的ΔCT正常，而当甲状旁腺功能亢进程度不足以导致碱性磷酸酶升高时，常存在增强的ΔCT。
