Onishi T, Deftos L J
Department of Medicine and Geriatrics, Osaka University Medical School, Japan.
Calcif Tissue Int. 1988 Mar;42(3):181-4. doi: 10.1007/BF02556331.
To study the effect of the kidney on blood calcitonin (CT), rats were made uremic by either total or partial nephrectomy or bilateral ligation of the ureters. Plasma CT concentrations were measured by radioimmunoassay before and after calcium infusion. Uremia induced by total or partial nephrectomy produced an increase in plasma CT. Rats had higher plasma CT levels (49.3 +/- 1.7 pg/ml, mean +/- SE) after total nephrectomy than after ureteral ligation (30.9 +/- 1.5 pg/ml) even though no significant difference was observed between the blood urea nitrogen (BUN) levels of these two groups. These results indicate that the kidney contributes to the degradation of CT.
为研究肾脏对血降钙素（CT）的影响，通过全肾或部分肾切除或双侧输尿管结扎使大鼠产生尿毒症。在钙输注前后，采用放射免疫分析法测定血浆CT浓度。全肾或部分肾切除诱导的尿毒症导致血浆CT升高。全肾切除术后大鼠的血浆CT水平（49.3±1.7 pg/ml，均值±标准误）高于输尿管结扎术后（30.9±1.5 pg/ml），尽管两组的血尿素氮（BUN）水平未观察到显著差异。这些结果表明，肾脏参与CT的降解。
