Neu I, Woelk H
Neurochem Res. 1982 Jun;7(6):727-35. doi: 10.1007/BF00965525.
Phospho- and galacto- lipids and lipidhydrolyzing enzymes have been determined in the white matter of a young patient with a subacute course of multiple sclerosis (MS). Significant changes were observed for the concentration of glycerophosphatides and the fatty acid pattern of the normal appearing with matter surrounding MS-plaques. Among the individual glycerophosphatides a significant decrease of phosphatidylserine and phosphatidylinositol was found, whereas the ethanolamine containing phosphatides showed lower figures (non significant). The fatty acid pattern of the ethanolamine-phosphatide-fraction of the diseased tissue a decrease of the 18:1 and the sum of 20:1 and 18:3 fatty acids as compared to the normal control, whereas the highly unsaturated, long-chained fatty acids 20:4 (arachidonic acid) and 22:6 (docosahexaenic acid) were elevated. The measurement of lipidhydrolyzing enzymes resulted in an increased phospholipase A1 activity in the diseased tissue. The experimental data point to a decreased activity of the fatty acid elongation system in the course of MS. The decrease of the acidic glycerophosphatides might be due to the increased phospholipase A1 activity.
在一名患有亚急性病程多发性硬化症（MS）的年轻患者的白质中，已对磷酸脂和半乳糖脂以及脂质水解酶进行了测定。在围绕MS斑块的正常外观白质中，观察到甘油磷脂浓度和脂肪酸模式有显著变化。在各个甘油磷脂中，发现磷脂酰丝氨酸和磷脂酰肌醇显著减少，而含乙醇胺的磷脂则显示较低数值（无统计学意义）。与正常对照相比，患病组织中乙醇胺磷脂部分的脂肪酸模式显示18:1以及20:1和18:3脂肪酸总和减少，而高度不饱和的长链脂肪酸20:4（花生四烯酸）和22:6（二十二碳六烯酸）升高。脂质水解酶的测定结果显示患病组织中磷脂酶A1活性增加。实验数据表明在MS病程中脂肪酸延长系统的活性降低。酸性甘油磷脂的减少可能归因于磷脂酶A1活性的增加。
