Kawamura S, Hattori S, Higo S, Matsuyama T
Neuroscience. 1982 Jul;7(7):1673-89. doi: 10.1016/0306-4522(82)90026-4.
Efferent projections from the cerebellar nuclei to the superior colliculus and the pretectum have been studied using both retrograde and orthograde labeling techniques in the cat. In order to identify what parts of the cerebellar nuclei project to the superior colliculus and the pretectum, the retrograde horseradish labeling technique was employed. In another set of experiments, tritiated amino acids were injected into each of the cerebellar regions from which the cerebello-tectal and cerebello-pretectal projections arise, and the laminar and spatial distributions of orthograde labeling in the superior colliculus and the pretectum were compared. The results showed that the cerebello-tectal projections arise from two different regions of the cerebellar nuclei: the caudal half of the medial nucleus and the ventrolateral part of the posterior interposed nucleus. Fibers arising from the medial nucleus distribute bilaterally in the superficial zone of the intermediate gray layer in the superior colliculus, while those originating from the posterior interposed nucleus terminate contralaterally in the deeper aspect of the intermediate gray layer and in the deep gray and white layers. Although the lateral nucleus does not contribute to the cerebello-tectal projection, it projects profusely to the pretectum contralaterally. The origin of the cerebello-pretectal projection lies in the parvicellular part of the lateral nucleus. Among several pretectal nuclei, the posterior pretectal, the medial pretectal nucleus and the reticular part of the anterior pretectal nucleus receive the cerebellar afferents. The findings of the differential projections from the cerebellum to the superior colliculus and the pretectum suggest that the cerebellum exerts a regulatory influence on visuo-motor and somato-motor transfer in these midbrain structures by differential circuits.
在猫身上，运用逆行和顺行标记技术对小脑核向中脑上丘和顶盖前区的传出投射进行了研究。为了确定小脑核的哪些部分投射到上丘和顶盖前区，采用了逆行辣根过氧化物酶标记技术。在另一组实验中，将氚标记的氨基酸注入小脑发出小脑 - 上丘和小脑 - 顶盖前区投射的各个区域，并比较上丘和顶盖前区内顺行标记的分层和空间分布。结果显示，小脑 - 上丘投射起源于小脑核的两个不同区域：内侧核的后半部和后间位核的腹外侧部。起源于内侧核的纤维双侧分布于上丘中间灰质层的浅部区域，而起源于后间位核的纤维则对侧终止于中间灰质层的深部以及深灰质和白质层。尽管外侧核不参与小脑 - 上丘投射，但它大量对侧投射到顶盖前区。小脑 - 顶盖前区投射起源于外侧核的小细胞部。在几个顶盖前核中，顶盖后核、顶盖内侧核和顶盖前核的网状部接受小脑传入纤维。小脑向中脑上丘和顶盖前区的不同投射结果表明，小脑通过不同的神经回路对这些中脑结构中的视觉 - 运动和躯体 - 运动转换施加调节影响。
