Urrutia Desmaison Julie D, Sala Romain W, Ayyaz Ahsan, Nondhalee Pimpimon, Popa Daniela, Léna Clément
Neurophysiology of Brain Circuits Team, Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, Paris, France.
Front Syst Neurosci. 2023 May 9;17:1176668. doi: 10.3389/fnsys.2023.1176668. eCollection 2023.
Fear learning is mediated by a large network of brain structures and the understanding of their roles and interactions is constantly progressing. There is a multitude of anatomical and behavioral evidence on the interconnection of the cerebellar nuclei to other structures in the fear network. Regarding the cerebellar nuclei, we focus on the coupling of the cerebellar fastigial nucleus to the fear network and the relation of the cerebellar dentate nucleus to the ventral tegmental area. Many of the fear network structures that receive direct projections from the cerebellar nuclei are playing a role in fear expression or in fear learning and fear extinction learning. We propose that the cerebellum, via its projections to the limbic system, acts as a modulator of fear learning and extinction learning, using prediction-error signaling and regulation of fear related thalamo-cortical oscillations.
恐惧学习由一个庞大的脑结构网络介导，对其作用和相互作用的理解也在不断发展。关于小脑核与恐惧网络中其他结构的相互连接，有大量的解剖学和行为学证据。关于小脑核，我们关注小脑顶核与恐惧网络的耦合以及小脑齿状核与腹侧被盖区的关系。许多直接接受小脑核投射的恐惧网络结构在恐惧表达、恐惧学习和恐惧消退学习中发挥作用。我们提出，小脑通过其向边缘系统的投射，利用预测误差信号和对与恐惧相关的丘脑 - 皮质振荡的调节，充当恐惧学习和消退学习的调节器。
