Hannigan E V, Whitehouse H H, Atkinson W D, Becker S N
Obstet Gynecol. 1982 Oct;60(4):450-5.
Under a diagnostic schema that used cervical conization liberally for evaluating women with abnormal Papanicolaou smears, 82 pregnant patients underwent conization. Fifteen had significant morbidity related to cervical bleeding. The uncorrected perinatal mortality was 44.1/1000. Sixty-one cone biopsies, performed before colposcopy was introduced into the schema, uncovered 2 cases of previously undiagnosed invasive carcinoma. Among 21 patients who underwent colposcopy before conization, 1 case of microinvasive carcinoma was diagnosed. During the study, 15 patients with frankly invasive carcinoma were identified, 9 by punch biopsy of a gross lesion, 2 by cone biopsy without prior colposcopy, and 4 by colposcopically directed punch biopsy. As a result of the review, the diagnostic schema has been changed so that biopsy is used less often on pregnancy patients.
在一种对巴氏涂片异常的女性广泛使用宫颈锥切术进行评估的诊断方案下，82名孕妇接受了锥切术。15名患者出现了与宫颈出血相关的严重并发症。未经校正的围产期死亡率为44.1/1000。在将阴道镜检查引入该方案之前进行的61例宫颈锥切活检中，发现了2例先前未被诊断出的浸润癌。在21例在锥切术前行阴道镜检查的患者中，诊断出1例微浸润癌。在研究期间，共识别出15例明确的浸润癌患者，其中9例通过对肉眼可见病变进行穿刺活检确诊，2例通过未先行阴道镜检查的锥切活检确诊，4例通过阴道镜引导下穿刺活检确诊。经过审查，诊断方案已有所改变，减少了对妊娠患者进行活检的频率。
