Viljoen J H, Coetzer J A
Onderstepoort J Vet Res. 1982 Mar;49(1):29-40.
More lesions were found in the carcass of an animal that has been naturally infested with Parafilaria bovicola than in one artificially infested with a single subcutaneous injection of infective larvae of this species. This may be because natural infestations are either more frequent or more successful. Similarities in the distribution of lesions in naturally and experimentally infested animals suggest that certain predilection sites may be used by the intermediate fly hosts. Subcutaneous areas infiltrated with eosinophils are more conspicuous during the first 20 days after infestation and during the patent phase of the life cycle of P. bovicola. Yellowish discolorations caused by oedema are usually present in all lesions. When these are combined with eosinophil infiltrations, the lesions become yellowish-green. After the appearance of bleeding spots the green colour of lesions is dominated by the appearance of a brown pigment (haemosiderin) in numerous macrophages. The histopathological changes in the dermis, subcutis and superficial muscles bordering the affected areas are described.
与单次皮下注射该物种感染性幼虫进行人工感染的动物相比，在自然感染牛副丝虫的动物胴体中发现了更多病变。这可能是因为自然感染要么更频繁，要么更成功。自然感染和实验感染动物的病变分布相似，这表明某些偏好部位可能被中间蝇宿主利用。在感染后的前20天以及牛副丝虫生命周期的显性期，嗜酸性粒细胞浸润的皮下区域更为明显。所有病变中通常都存在由水肿引起的淡黄色变色。当这些与嗜酸性粒细胞浸润相结合时，病变变为黄绿色。出血点出现后，病变的绿色被大量巨噬细胞中棕色色素（含铁血黄素）的出现所主导。描述了受影响区域周围真皮、皮下组织和浅表肌肉的组织病理学变化。
