Viljoen J H, Boomker J D
Onderstepoort J Vet Res. 1977 Jun;44(2):107-12.
The filaricidal effects of trichlorphon, arsenic trioxide, sodium antimony biscathecol disulphonate and nitroxynil against Parafilaria bovicola were the subject of this investigation. Levamisole hydrochooride was retested in a separate trial to assess the time required for healing after successful treatment. A comparison of carcass lesions and the percentage of lesion area in untreated controls with those in treated animals reconfirmed the efficacy of levamisole hydrochlorice, while nitroxynil gave more promising results. Both lesions and lesion area were reduced by 76% by the former and by 93% by the latter compound. The other drugs only slightly suppressed P. bovicola activity. After treatment with levamisole hydrochloride, active lesions were still present for 1-4 weeks and visible lesions on slaughter for 8 weeks. Since the visible lesions during the 8 weeks varied from acute to chronic and as they disappeared 9 weeks post treatment, it is suggested that provision should be made for a healing period of at least 9 weeks.
本研究旨在探讨敌百虫、三氧化二砷、酒石酸锑钾和硝氯酚对牛副丝虫的杀丝虫作用。在一项单独试验中对盐酸左旋咪唑进行了重新测试，以评估成功治疗后愈合所需的时间。将未治疗对照组的胴体损伤及损伤面积百分比与治疗动物的进行比较，再次证实了盐酸左旋咪唑的疗效，而硝氯酚的效果更有前景。前者使损伤及损伤面积减少了76%，后者使损伤及损伤面积减少了93%。其他药物仅轻微抑制牛副丝虫的活性。用盐酸左旋咪唑治疗后，活动性损伤仍持续1 - 4周，屠宰时可见损伤持续8周。由于这8周内可见损伤从急性转变为慢性，且在治疗后9周消失，因此建议规定至少9周的愈合期。
