Broccardo M
Pharmacol Res Commun. 1985 Apr;17(4):345-50. doi: 10.1016/0031-6989(85)90014-1.
The development of tolerance to the effect of dermorphin on gastric emptying (G.E.) induced by repeated subcutaneous (s.c.), intracerebroventricular (i.c.v.) injections or by i.c.v. infusion of this peptide, was studied in rats. Dermorphin produced a delay in G.E. when it was injected i.c.v. or s.c., but when for 5 days rats were injected twice daily with the same dose of peptide, the acute i.c.v. injection of dermorphin no longer produced a significant delay in G.E. demonstrating an establishment of tolerance to this effect. However, 10 days were necessary to establish tolerance to s.c. injection of the peptide. When dermorphin was i.c.v. infused by a minipump, tolerance to delay of G.E. was inversely proportional to infusion time and it took 2 days to establish tolerance to this peripheral effect. These data suggest the possibility that different development mechanisms: of dermorphin-induced tolerance seem to exists for gastrointestinal responses as compared to other effects of dermorphin, analgesia and catalepsy.
在大鼠中研究了重复皮下（s.c.）、脑室内（i.c.v.）注射或脑室内输注这种肽后，大鼠对德莫啡肽对胃排空（G.E.）作用的耐受性发展情况。当脑室内或皮下注射德莫啡肽时，它会导致胃排空延迟，但当大鼠连续5天每天两次注射相同剂量的肽后，急性脑室内注射德莫啡肽不再能显著延迟胃排空，这表明对该作用产生了耐受性。然而，需要10天才能建立起对皮下注射该肽的耐受性。当通过微型泵进行脑室内输注德莫啡肽时，对胃排空延迟的耐受性与输注时间成反比，并且需要2天才能建立起对这种外周作用的耐受性。这些数据表明，与德莫啡肽的其他作用（镇痛和僵住症）相比，德莫啡肽诱导的耐受性在胃肠道反应中似乎存在不同的发展机制。
