胎鼠肝脏中的腺嘌呤核苷酸浓度。早产儿的新生儿期变化。

Adenine nucleotide concentrations in liver of fetal rats. Neonatal changes in the premature newborn.

作者信息

Cuezva J M, Medina J M

出版信息

Rev Esp Fisiol. 1982 Jun;38(2):161-6.

Abstract

Changes in ATP, ADP and AMP concentrations in the liver in term and preterm newborns during the perinatal period have been studied. Fetal liver ATP concentrations decreased during the penultimate day of gestation and remained low during the last day of pregnancy. ATP concentrations sharply increased in the liver of term newborns immediately after delivery, remaining unchanged after 1 h of extrauterine life. High ATP concentrations were observed in the liver of preterm newborns at delivery without changes within the early postnatal period. No significant changes in liver ADP and AMP concentrations were observed in either group throughout the observation period. Energy charge was higher in preterm liver at delivery but similar values were reached in term liver after 30 min of extrauterine life. These results suggest that the energy stage of the preterm liver is high at delivery without changes during the early postnatal period.

摘要

对足月儿和早产儿围产期肝脏中三磷酸腺苷（ATP）、二磷酸腺苷（ADP）和一磷酸腺苷（AMP）浓度的变化进行了研究。胎肝ATP浓度在妊娠倒数第二天下降，并在妊娠最后一天保持较低水平。足月儿出生后肝脏中的ATP浓度立即急剧增加，出生后1小时保持不变。早产儿出生时肝脏中ATP浓度较高，出生后早期无变化。在整个观察期内，两组肝脏中的ADP和AMP浓度均未观察到显著变化。早产儿出生时肝脏的能荷较高，但足月儿出生后30分钟肝脏能荷达到相似值。这些结果表明，早产儿肝脏在出生时能量状态较高，出生后早期无变化。