Depletion of phenylalanine in the blood of phenylketonuric patients using a PAL-enzyme reactor. An in vitro study.
作者信息
Ambrus C M, Horváth C, Kalghatgi K, Clowsley M, Huzella C, Warner R, Ambrus J L, Cooley C M, Mirand E A
出版信息
Res Commun Chem Pathol Pharmacol. 1982 Jul;37(1):105-11.
PMID:7122995
Abstract
Blood samples obtained from eight adult phenylketonuric individuals had a mean phenylalanine level of 25 mg/dl. When these samples were circulated through multitubular enzyme-reactors prepared with immobilized phenylalanine ammonia lyase an average of 77% of phenylalanine was metabolized within 30 minutes. We conclude that phenylalanine in human phenylketonuric blood is just as susceptible to metabolism by PAL-enzyme reactors as phenylalanine that is added to normal blood, or that is circulating in dogs and monkeys made hyperphenylalaninemic by experimental means.
摘要
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