Meyer R L
Science. 1982 Nov 5;218(4572):589-91. doi: 10.1126/science.7123262.
Optic fibers from both eyes were made to regenerate simultaneously into one tectum in goldfish. Autoradiography at various times later revealed that regenerating left and right fibers overlapped extensively for up to 4 weeks and subsequently segregated into eye dominance columns by 8 weeks. Continuous tetrodotoxin treatment of both eyes prevented the formation of columns for up to 13 weeks and was equally effective if begun at 6 weeks. When tetrodotoxin treatment was stopped after 11 weeks, columns subsequently formed in the next 3 weeks. Blockade of only one eye did prevent column formation at 8 weeks.
使金鱼双眼的视神经纤维同时再生至同一个视顶盖中。在随后不同时间进行的放射自显影显示，再生的左右眼纤维广泛重叠长达4周，随后在8周时分离成眼优势柱。对双眼持续进行河豚毒素处理可在长达13周的时间内阻止柱的形成，若在6周时开始处理，效果同样显著。当河豚毒素处理在11周后停止时，柱在接下来的3周内形成。仅阻断一只眼确实会在8周时阻止柱的形成。
