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[流感病毒蛋白合成对细胞DNA转录的抑制作用]

[Synthesis of influenza virus protein in the inhibition of cellular DNA transcription].

作者信息

Kantorovich-Prokudina E N, Semenova N P, Berezina O N

出版信息

Vopr Virusol. 1982 May-Jun;27(3):287-93.

PMID:7123908
Abstract

After preliminary UV-irradiation of cells as well as in the presence of actinomycin D the doses of both agents inhibiting influenza virus production are slightly lower than those inhibiting formation of viral proteins and considerably lower than those producing complete blocking of viral genome expression. These data demonstrate the existence of a cellular DNA-dependent factor the blocking of which prevents the formation of virus progeny without preventing primary transcription and formation of virion proteins. It is assumed that, apart from relatively small genes of cellular DNA participating in primary transcription of viral genome, some larger genes of the cell take part in some process of influenza virus reproduction.

摘要

在对细胞进行初步紫外线照射后以及在放线菌素D存在的情况下,两种抑制流感病毒产生的试剂剂量略低于抑制病毒蛋白形成的剂量,且远低于完全阻断病毒基因组表达的剂量。这些数据表明存在一种细胞DNA依赖性因子,阻断该因子可阻止病毒后代的形成,而不会阻止病毒基因组的初级转录和病毒粒子蛋白的形成。据推测,除了参与病毒基因组初级转录的细胞DNA相对较小的基因外,细胞的一些较大基因也参与了流感病毒复制的某些过程。

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