Arshavskiĭ I A, Mikhaĭlichenko L A
Zh Evol Biokhim Fiziol. 1982 Jul-Aug;18(4):380-6.
In connection with data on the absence of spinal forms of reciprocal inhibition in ante natal and early postnatal periods in puppies, it was decided to use strychninization as a physiological tool which enables to evaluate the onset of the activity of the inhibitory interneurones which are involved into realization of postsynaptic inhibition. Experiments were made on puppies from three age groups (up to 5 days 8--10 days and 20--30 days) in which mono- and polysynaptic reactions to afferent stimulation were recorded. It was established that the onset of the activity of inhibitory interneurones in the developing neuronal system takes place after realization of antigravitational reactions. At the age of 10--30 days, block of postsynaptic inhibition by strychnine returns the spinal cord to that type of reactions which are typical of antenatal and early postnatal periods.
鉴于有关幼犬出生前和出生后早期不存在脊髓形式的交互抑制的数据,决定使用士的宁化作为一种生理工具,以评估参与突触后抑制实现的抑制性中间神经元活动的开始。对三个年龄组(5天以下、8 - 10天和20 - 30天)的幼犬进行了实验,记录了对传入刺激的单突触和多突触反应。已确定,在发育中的神经元系统中,抑制性中间神经元活动的开始发生在抗重力反应实现之后。在10 - 30天龄时,士的宁对突触后抑制的阻断使脊髓恢复到出生前和出生后早期典型的反应类型。