Croxatto H B, Díaz S, Peralta O, Salvatierra A M, Brandeis A
Acta Endocrinol (Copenh). 1982 Aug;100(4):630-3. doi: 10.1530/acta.0.1000630.
The magnitude and duration of elevated plasma progesterone levels resulting from subdermal implantation of progesterone pellets were investigated in full nursing women. This condition was chosen because it is associated with a low rate of ovulation and minimal endogenous progesterone production. In addition, treatment with progesterone pellets was intended to be a substitute for oral or parenteral administration of synthetic progestogens to nursing mothers. A control group of full nursing women receiving no hormones provided blood samples so that basal plasma progesterone levels from the second to the sixth post-partum month could be assessed. Progesterone pellets were implanted subdermally on day 30-35 after delivery. Insertion of 2, 4 or 6 pellets each containing 100 mg of progesterone caused an initial elevation of plasma progesterone to 5.9, 9.9 and 13.5 nmol/l, respectively. This initial elevation was followed by a gradual decline, so that basal levels were attained at 70, 100 and 150 days after insertion of 2, 4 or 6 pellets. Implantation of 6 progesterone pellets led to a significant decrease in the ovulation rate of nursing women. These results indicate that subdermal implantation of 6 progesterone pellets can provide biologically effective levels of the hormone for up to 5 months.
对完全哺乳期妇女进行研究，以探讨皮下植入孕酮丸剂后血浆孕酮水平升高的幅度和持续时间。选择这种情况是因为它与低排卵率和极少的内源性孕酮产生有关。此外，使用孕酮丸剂治疗旨在替代向哺乳期母亲口服或胃肠外给予合成孕激素。一组未接受激素的完全哺乳期妇女作为对照组提供血样，以便评估产后第二个月至第六个月的基础血浆孕酮水平。在分娩后第30 - 35天皮下植入孕酮丸剂。分别植入2、4或6粒每粒含100毫克孕酮的丸剂，导致血浆孕酮最初分别升高至5.9、9.9和13.5纳摩尔/升。这种最初的升高之后是逐渐下降，因此在植入2、4或6粒丸剂后70、100和150天达到基础水平。植入6粒孕酮丸剂导致哺乳期妇女排卵率显著降低。这些结果表明，皮下植入6粒孕酮丸剂可在长达5个月的时间内提供生物学有效水平的该激素。
