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哺乳期妇女的生育调节。II. 孕酮植入剂与安慰剂及铜T的比较性能

Fertility regulation in nursing women. II. Comparative performance of progesterone implants versus placebo and copper T.

作者信息

Croxatto H B, Díaz S, Peralta O, Juez G, Casado M E, Salvatierra A M, Durán E

出版信息

Am J Obstet Gynecol. 1982 Sep 15;144(2):201-8.

PMID:7114130
Abstract

A clinical study was designed to test whether sustained administration of progesterone to nursing mothers could prolong lactation and delay the postpartum recovery of fertility. The hormone was administered by subdermal implantation of six pellets that each contained 100 mg of progesterone. This treatment was administered to 84 fully nursing women on day 30 post partum. Control groups were composed of 130 fully nursing women who received an injectably placebo, and by 125 fully nursing women who received a TCu 200 intrauterine contraceptive device. An exacting list of requirements for admission to and continuation in the study was applied to all groups. No pregnancies occurred in the progesterone-treated group from the second to the sixth postpartum month. This period coincided with the period of elevation plasma progesterone attributable to hormone released from the implants. The cumulative probability of pregnancy in the placebo group was 10.2 per 100 women at the sixth month. Treatment with progesterone did not change the duration of lactation or the rate of child growth, and no adverse effects were recorded. These results warrant further investagation of the use of progesterone as an alternative method to prevent conception in nursing women.

摘要

一项临床研究旨在测试向哺乳期母亲持续施用孕酮是否可以延长哺乳期并延迟产后生育能力的恢复。通过皮下植入六颗每颗含有100毫克孕酮的药丸来施用该激素。在产后第30天,对84名完全母乳喂养的妇女进行了这种治疗。对照组由130名接受注射用安慰剂的完全母乳喂养妇女和125名接受TCu 200宫内节育器的完全母乳喂养妇女组成。对所有组都应用了严格的研究入选和持续要求清单。在产后第二个月至第六个月,孕酮治疗组未发生妊娠。这一时期与植入物释放的激素导致血浆孕酮升高的时期相吻合。安慰剂组在第六个月时每100名妇女的累积妊娠概率为10.2。孕酮治疗并未改变哺乳期的持续时间或儿童生长速度,且未记录到不良反应。这些结果值得进一步研究将孕酮用作哺乳期妇女预防怀孕的替代方法。

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Am J Obstet Gynecol. 1982 Sep 15;144(2):201-8.
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Cochrane Database Syst Rev. 2015 Mar 20;2015(3):CD003988. doi: 10.1002/14651858.CD003988.pub2.