Driessen J J, Smets M J, Goey L S, Booij L H
Acta Anaesthesiol Belg. 1982;33(2):99-105.
A randomized double blind comparison between diazepam 10 mg, and midazolam 15 mg as oral premedicants in diagnostic fiber optic bronchoscopy under local anesthesia was made. The subjective assessments by the patient, the observer and the bronchoscopist showed that midazolam 15 mg orally gives an at least comparable degree of sedation, relief of anxiety and patient's tolerance as diazepam 10 mg orally. Midazolam 15 mg gives some degree of anterograde amnesia where diazepam 10 mg completely fails. Psychomotor recovery after 4 hours is better after midazolam 15 mg than after diazepam 10 mg. No adverse reactions were seen with both premedicants.
在局部麻醉下进行诊断性纤维支气管镜检查时，对10毫克地西泮和15毫克咪达唑仑作为口服术前用药进行了随机双盲比较。患者、观察者和支气管镜检查医生的主观评估表明，口服15毫克咪达唑仑产生的镇静程度、焦虑缓解程度和患者耐受性至少与口服10毫克地西泮相当。15毫克咪达唑仑会产生一定程度的顺行性遗忘，而10毫克地西泮则完全没有这种作用。15毫克咪达唑仑用药后4小时的精神运动恢复情况比10毫克地西泮更好。两种术前用药均未观察到不良反应。
