Kolek V, Jezdinský J
Clinic of Tuberculosis and Respiratory Diseases, University Hospital with Policlinic, Olomouc, Czechoslovakia.
Acta Univ Palacki Olomuc Fac Med. 1991;131:233-41.
Two types of benzodiazepines were used in premedication of flexible bronchoscopy. The agents were introduced in randomized, double-blind trial. Midazolam (Dormicum Hoffmann-La Roche AG) was given to 21 patients (0.07 mg/kg i.v.), diazepam (Seduxen Richter) to 22 patients (0.14 mg/kg i.v.) and placebo (saline) to 20 patients (0.07 ml/kg i.v.). Vigility, motor functions and anxiety were estimated from the application to 3 hours after endoscopy. Breathing, pulse rate, blood pressure and local reactions were followed as well. The course of bronchoscopy, anterograde amnesia and acceptability of further intervention were evaluated. Midazolam offered short term action, stronger sedative and anxiolytic effect than diazepam (48% to 27%). The anterograde amnesia was more frequent (90.5% to 55% in diazepam), acceptability of further bronchoscopy after midazolam was present in 95% of patients, after diazepam in 86% of patients. These favourable properties can be utilized especially in cases with enhanced anxiety and necessity of further endoscopies.
两种苯二氮䓬类药物用于可弯曲支气管镜检查的术前用药。这些药物在随机双盲试验中使用。21例患者静脉注射咪达唑仑（多美康，霍夫曼-罗氏公司）（0.07 mg/kg），22例患者静脉注射地西泮（速可眠，里奇特公司）（0.14 mg/kg），20例患者静脉注射安慰剂（生理盐水）（0.07 ml/kg）。在内镜检查开始至结束后3小时期间评估患者的警觉性、运动功能和焦虑情况。同时监测呼吸、脉搏率、血压和局部反应。评估支气管镜检查过程、顺行性遗忘以及进一步干预的可接受性。咪达唑仑起效迅速，镇静和抗焦虑作用比地西泮更强（分别为48%和27%）。顺行性遗忘更为常见（地西泮组为55%，咪达唑仑组为90.5%），咪达唑仑组95%的患者可接受进一步的支气管镜检查，地西泮组为86%。这些良好特性尤其可用于焦虑情绪增强且需要进一步进行内镜检查的情况。
