镉和锰对部分肝切除大鼠体内铁-59分布的影响。

The effect of cadmium and manganese on the distribution of iron-59 in partially-hepatectomized rats.

作者信息

Srivastava R C, Kaur G, Srivastava R, Dwivedi R S

出版信息

Acta Pharmacol Toxicol (Copenh). 1982 Jul;51(1):20-3. doi: 10.1111/j.1600-0773.1982.tb01057.x.

DOI:10.1111/j.1600-0773.1982.tb01057.x

Abstract

The distribution of iron-59 in blood at various time intervals was studied in sham and partially-hepatectomized rats after a single intravenous injection of 59Fe (III) citrate. A significant difference was observed in the rate of disappearance and reappearance of iron-59 in circulation. Administration of cadmium and manganese at a concentration of 0.5 and 2 mg/kg b.wt., respectively, did not cause any significant change in this pattern. A significant decrease in iron-59 incorporation in the liver of hepatectomized rat was produced by cadmium while manganese had no effect.

摘要

在单次静脉注射柠檬酸铁（III）后，研究了假手术组和部分肝切除大鼠在不同时间间隔时血液中铁-59的分布情况。观察到循环中铁-59的消失和重新出现速率存在显著差异。分别以0.5毫克/千克体重和2毫克/千克体重的浓度给予镉和锰，并未使这种模式发生任何显著变化。镉导致部分肝切除大鼠肝脏中铁-59的掺入量显著降低，而锰则没有影响。