Margeli A, Theocharis S, Skaltsas S, Skopelitou A, Mykoniatis M
Department of Experimental Pharmacology, Medical School, University of Athens, Greece.
Environ Health Perspect. 1994 Sep;102 Suppl 3(Suppl 3):273-6. doi: 10.1289/ehp.94102s3273.
Cadmium is a nonabundant element that is widely distributed throughout the biosphere and its toxic effects are becoming potentially more serious due to industrialization. It has been reported that cadmium might interact with nucleic acid biosynthesis. In this study we examined the effect of cadmium administration, either 24 hr before or simultaneously to partial hepatectomy, on the liver regenerative process in rats, at different time intervals. The rate of DNA synthesis was suppressed markedly in the cadmium pretreated group and the first peak of liver regeneration was delayed, compared to the simply partially hepatectomized one. The administration of cadmium simultaneously to partial hepatectomy, caused a marked decrease of the rate of DNA biosynthesis, compared to the pretreatment. The rate-determining enzyme thymidine kinase was suppressed in the liver of both cadmium-treated groups. Biochemical parameters and histological findings were also coestimated. The above data suggest that either pre- or simultaneous administration of cadmium, suppressed the liver regenerative process, probably due to the inhibition of thymidine kinase.
镉是一种含量不丰富的元素，广泛分布于整个生物圈，由于工业化，其毒性作用可能正变得愈发严重。据报道，镉可能与核酸生物合成相互作用。在本研究中，我们在不同时间间隔下，研究了在大鼠部分肝切除术前24小时或同时给予镉，对肝脏再生过程的影响。与单纯部分肝切除的大鼠相比，镉预处理组的DNA合成速率显著受到抑制，肝脏再生的第一个峰值延迟。与预处理相比，在部分肝切除的同时给予镉，导致DNA生物合成速率显著降低。在两个镉处理组的肝脏中，限速酶胸苷激酶均受到抑制。同时还共同评估了生化参数和组织学结果。上述数据表明，术前或同时给予镉均会抑制肝脏再生过程，这可能是由于胸苷激酶受到抑制所致。
