多胺羧酸对假手术和部分肝切除大鼠体内器官中锰-54清除的影响。

Influence of polyaminocarboxylic acids on the removal of manganese-54 from the body organs of sham-operated and partially hepatectomized rats.

作者信息

Kaur G, Srivastava U C, Dwivedi R S, Srivastava R C

出版信息

Toxicol Lett. 1984 Jul;22(1):1-6. doi: 10.1016/0378-4274(84)90037-7.

Abstract

EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in early manganese (Mn) poisoning. CDTA was found to be most effective in removing 54Mn from the liver of both sham-operated and hepatectomized rats. These chelating agents also lowered the Mn levels in kidney, spleen and brain of poisoned rats. Although a significantly higher accumulation of Mn was observed in hepatectomized rats, there was no significant difference in the efficiency of the chelating agents in removing Mn from the body organs of poisoned animals of both the sham-operated and hepatectomized groups. An attempt has been made to seek a possible correlation between % removal of Mn by various polyaminocarboxylic acids and their corresponding stability constants.

摘要

在锰（Mn）中毒早期，研究了乙二胺四乙酸（EDTA）、1,2-环己二胺四乙酸（CDTA）、六亚甲基-1,6-二胺-N,N,N',N'-四乙酸（HDTA）、二乙烯三胺五乙酸（DTPA）和次氮基三乙酸（NTA）从假手术和部分肝切除大鼠的某些器官中去除锰-54（⁵⁴Mn）的情况。发现CDTA在从假手术和肝切除大鼠的肝脏中去除⁵⁴Mn方面最有效。这些螯合剂也降低了中毒大鼠肾脏、脾脏和大脑中的锰水平。尽管在肝切除大鼠中观察到锰的蓄积明显更高，但在假手术组和肝切除组中毒动物的身体器官中，螯合剂去除锰的效率没有显著差异。已尝试寻找各种聚氨基羧酸去除锰的百分比与其相应稳定常数之间的可能相关性。