Lancaster-Smith M J, Prout B J, Pinto T, Anderson J A, Schiff A A
Acta Psychiatr Scand. 1982 Jul;66(1):33-41. doi: 10.1111/j.1600-0447.1982.tb00912.x.
Sixty per cent of the patients referred to two gastroenterological clinics and diagnosed as suffering from the irritable bowel syndrome (IBS), were found to have significant psychoneurotic morbidity on the basis of the General Health Questionnaire. A double-blind, completely randomised, placebo controlled comparison of treatment with a combined anxiolytic/antidepressant (Motipress) found a significantly better effect of Motipress than placebo on diarrhoea and abdominal pain. Detailed analysis of the results suggests that there is no direct relationship between psychoneurotic illness and IBS, but the presence of the former has an adverse effect on the short-term outcome of the bowel disorder.
在被转诊至两家胃肠病诊所并被诊断为患有肠易激综合征（IBS）的患者中，根据一般健康问卷发现，60%的患者存在明显的精神神经症发病率。一项对一种抗焦虑/抗抑郁联合药物（Motipress）进行的双盲、完全随机、安慰剂对照治疗比较发现，Motipress在治疗腹泻和腹痛方面的效果明显优于安慰剂。对结果的详细分析表明，精神神经症与IBS之间没有直接关系，但前者的存在对肠道疾病的短期预后有不利影响。
