Zweifler A J, Nicholls M G
Am Heart J. 1982 Oct;104(4 Pt 1):812-5. doi: 10.1016/0002-8703(82)90016-3.
Digital volume pulse maximum dilation was determined in 27 patients with borderline essential hypertension (BHT) and 28 age-matched normotensive controls (NT). Finger pulse volume (PV) and finger systolic pressure (SBP) were measured by pneumoplethysmography during vasodilation induced by combining direct and reflex heat dilation and reactive hyperemia. Finger SBP was higher (p less than 0.01) in BHT than in NT (120 +/- 18.7 vs. 104 +/- 14.8 mm Hg, respectively); PV was lower (p less than 0.01) in BHT than in NT (9.7 +/- 4.2 vs. 15.3 +/- 6 ml/5 ml finger X 10(-3). Pulse volume correlated inversely with SBP in BHT (r = -0.40, p less than 0.05) but was unrelated to SBP in NT. Pulse volume was not altered by high or low sodium intake in BHT or NT despite significant changes in plasma renin activity (PRA). In BHT finger vessels are less distensible at a higher pressure than in NT. This abnormality is demonstrable during maneuvers to withdraw sympathetic tone and is not influenced by alteration of PRA. These data support the concept that BHT can produce structural vascular change, and demonstrate that this abnormality can be detected by a relatively simple method.
对27例临界原发性高血压（BHT）患者和28例年龄匹配的血压正常对照者（NT）测定数字容积脉搏最大扩张度。在直接和反射性热扩张及反应性充血联合诱导的血管扩张过程中，采用空气容积描记法测量手指脉搏容积（PV）和手指收缩压（SBP）。BHT患者的手指SBP高于NT（分别为120±18.7与104±14.8mmHg，p<0.01）；BHT患者的PV低于NT（分别为9.7±4.2与15.3±6ml/5ml手指×10⁻³，p<0.01）。在BHT中，脉搏容积与SBP呈负相关（r = -0.40，p<0.05），但在NT中与SBP无关。尽管血浆肾素活性（PRA）有显著变化，但BHT或NT患者的高钠或低钠摄入均未改变脉搏容积。与NT相比，BHT患者的手指血管在较高压力下扩张性较小。这种异常在降低交感神经张力的操作过程中可被证实，且不受PRA改变的影响。这些数据支持BHT可导致血管结构改变的概念，并表明这种异常可通过一种相对简单的方法检测到。
