Armstrong M J, Stephan Z, Hayes K C
Am J Clin Nutr. 1982 Oct;36(4):592-601. doi: 10.1093/ajcn/36.4.592.
The separate effects contributed by dietary cholesterol and dietary fat on several parameters of biliary lipid metabolism thought to be important in the genesis of cholesterol gallstones were examined in squirrel and cebus monkeys fed diets containing either corn or coconut oil from birth. Half the monkeys were also fed cholesterol. In gallstone-susceptible squirrel monkeys, corn oil tended to decrease the bile acid pool size and decrease the percentage of taurochenodeoxycholic acid. Dietary cholesterol effected major changes in gallbladder bile molar percent lipid composition with significantly increased cholesterol saturation indices that exceeded the metastable-labile limits. The supersaturated biles notwithstanding, none of the monkeys developed gallstones and only one had cholesterol crystals in its bile. By contrast, the gallstone-resistant cebus monkeys experienced less remarkable shifts in biliary lipid composition during dietary challenges of cholesterol and fat. The data are consistent with the hypothesis that neither a diminished bile acid pool size nor bile supersaturated with cholesterol are sufficient in themselves to result in gallstone formation in immature monkeys.
在从出生起就喂食含玉米油或椰子油饮食的松鼠猴和卷尾猴中，研究了膳食胆固醇和膳食脂肪对几种被认为在胆固醇胆结石形成中起重要作用的胆汁脂质代谢参数的单独影响。一半的猴子还喂食了胆固醇。在易患胆结石的松鼠猴中，玉米油倾向于减小胆汁酸池大小并降低牛磺鹅去氧胆酸的百分比。膳食胆固醇使胆囊胆汁脂质摩尔百分比组成发生重大变化，胆固醇饱和指数显著增加，超过了亚稳 - 不稳定极限。尽管胆汁呈过饱和状态，但没有一只猴子形成胆结石，只有一只猴子的胆汁中有胆固醇晶体。相比之下，抗胆结石的卷尾猴在胆固醇和脂肪饮食挑战期间，胆汁脂质组成的变化不太明显。这些数据与以下假设一致：胆汁酸池大小减小或胆汁中胆固醇过饱和本身都不足以导致未成熟猴子形成胆结石。
