Lee D W, Gilmore C J, Bonorris G, Cohen H, Marks J W, Cho-Sue M, Meiselman M S, Schoenfield L J
Am J Clin Nutr. 1985 Sep;42(3):414-20. doi: 10.1093/ajcn/42.3.414.
The purpose of this study was to determine the effect of dietary cholesterol on biliary lipids in subjects with and without gallstones. Twelve patients with asymptomatic gallstones (six men, six women) were assigned diets containing 500, 750, and 1000 mg cholesterol daily for 3-wk periods in random sequence. Seven healthy women similarly were assigned diets containing 500 and 1000 mg cholesterol daily. With increasing dietary cholesterol in patients with gallstones, biliary saturation indices and molar percents of cholesterol and phospholipids increased significantly while molar percent of biliary bile acids decreased significantly. With increasing dietary cholesterol in healthy women, the biliary saturation index and molar percent of cholesterol increased significantly; the mean saturation index exceeded unity on the diet containing 1000 mg cholesterol daily. In conclusion, augmented dietary cholesterol for brief periods increased biliary cholesterol saturation in subjects with and without gallstones.
本研究的目的是确定膳食胆固醇对有胆结石和无胆结石受试者胆汁脂质的影响。12例无症状胆结石患者（6名男性，6名女性）被随机安排在3周的时间段内，依次食用每日含500、750和1000毫克胆固醇的饮食。7名健康女性同样被安排食用每日含500和1000毫克胆固醇的饮食。随着胆结石患者膳食胆固醇的增加，胆汁饱和指数以及胆固醇和磷脂的摩尔百分比显著增加，而胆汁酸的摩尔百分比显著下降。随着健康女性膳食胆固醇的增加，胆汁饱和指数和胆固醇的摩尔百分比显著增加；在每日含1000毫克胆固醇的饮食中，平均饱和指数超过了1。总之，短期内增加膳食胆固醇会使有胆结石和无胆结石的受试者胆汁胆固醇饱和度增加。
