Gipstein R M, Adams D A, Grabie M T, Peter J B
Am J Med Sci. 1982 Sep-Oct;284(2):37-41. doi: 10.1097/00000441-198209000-00006.
A case of post-partum SLE in a 25-year-old Mexican-American woman is presented. The disease was associated with systemic vasculitis and diffuse proliferative glomerulonephritis. Abundant evidence for the deposition of complement activating immune complexes was found in skin and kidney biopsies, but no circulating immune complexes could be measured. Therapeutic modalities including corticosteroids administered both orally and intravenously, azathioprine, antihypertensives, and hemodialysis failed to effectuate lasting benefit. Large volume plasmapheresis led to immediate improvement and a dramatic return of renal function. A mechanism of action for the resulting effect is considered.
本文报告了一名25岁墨西哥裔美国女性产后系统性红斑狼疮（SLE）的病例。该疾病与系统性血管炎和弥漫性增殖性肾小球肾炎相关。在皮肤和肾脏活检中发现了大量补体激活免疫复合物沉积的证据，但未检测到循环免疫复合物。包括口服和静脉注射皮质类固醇、硫唑嘌呤、抗高血压药和血液透析在内的治疗方法均未能产生持久疗效。大剂量血浆置换导致病情立即改善，肾功能显著恢复。本文还探讨了由此产生疗效的作用机制。
