自杀行为的神经内分泌危险因素。
Neuroendocrine risk factors of suicidal behavior.
作者信息
Ostroff R, Giller E, Bonese K, Ebersole E, Harkness L, Mason J
出版信息
Am J Psychiatry. 1982 Oct;139(10):1323-5. doi: 10.1176/ajp.139.10.1323.
Three of 22 subjects in a study of neuroendocrine correlates of clinical change made serious suicide attempts, 2 of which were lethal. The suicidal subjects had significantly higher 24-hour urinary cortisol levels and significantly lower 24-hour urinary norepinephrine-to-epinephrine ratios than the nonsuicidal patients had. Although the cortisol finding confirms earlier reports, the norepinephrine-to-epinephrine ratio finding is new. The results support the concept that the clinical utility of neuroendocrine measures is enhanced by using a multihormonal profile.
在一项关于临床变化的神经内分泌相关性研究中，22名受试者中有3人曾有过严重的自杀未遂行为，其中2例自杀身亡。与未自杀的患者相比，有自杀行为的受试者24小时尿皮质醇水平显著更高，24小时尿去甲肾上腺素与肾上腺素的比值显著更低。虽然皮质醇的研究结果证实了早期的报道，但去甲肾上腺素与肾上腺素比值的研究结果却是新的。这些结果支持了这样一种观点，即通过使用多种激素指标可以提高神经内分泌测量的临床效用。
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