Thorell L H, Kjellman B F, d'Elia G, Kågedal B
Department of Psychiatry, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Acta Psychiatr Scand. 1988 Dec;78(6):743-53. doi: 10.1111/j.1600-0447.1988.tb06414.x.
Electrodermal activity (EDA), basal morning plasma cortisol, outcome of the dexamethasone suppression test (DST), and nocturnal urinary cortisol excretion were studied in a somewhat confined number of originally 59 depressive patients and 59 matched healthy subjects. The patients showed nocturnal hypercortisolism. According to the DST, EDA and cortisol dysregulation were unrelated. In the total patient group, the correlations between EDA and cortisol in plasma and in urine were small and insignificant. However, in suicide attempters, in nonsuicidal patients, and in the healthy subjects, complex patterns of correlations were found between tonic electrodermal activity, electrodermal responsivity, basal morning plasma cortisol, and nocturnal urinary cortisol. Some inconsistencies in the patterns may be explained by differences in the sampling of data. Future research should try to delineate possible relationships between EDA and hormones on all levels of the hypothalamic-pituitary-adrenocortical axis.
在最初的59名抑郁症患者和59名匹配的健康受试者中，研究了皮肤电活动（EDA）、晨间基础血浆皮质醇、地塞米松抑制试验（DST）结果以及夜间尿皮质醇排泄情况。患者表现出夜间皮质醇增多症。根据DST结果，EDA与皮质醇失调无关。在整个患者组中，血浆和尿液中EDA与皮质醇之间的相关性较小且无统计学意义。然而，在自杀未遂者、非自杀患者和健康受试者中，发现静息皮肤电活动、皮肤电反应性、晨间基础血浆皮质醇和夜间尿皮质醇之间存在复杂的相关性模式。这些模式中的一些不一致可能由数据采样差异来解释。未来的研究应尝试阐明下丘脑-垂体-肾上腺皮质轴各级上EDA与激素之间的可能关系。
