Clark R M, Rosen I B, Laperriere N J
Am J Surg. 1982 Oct;144(4):459-62. doi: 10.1016/0002-9610(82)90423-8.
Malignant tumors in the head and neck region are rare in patients under the age of 30 years. The survival rate in our group compared favorably with the rate for adults with similar tumors and supports the administration of aggressive treatment. Radiation therapy in the formative years can arrest skeletal growth and cause tissue atrophy which produces facial asymmetry, but it does give in balance a better functional result and less mutilation than does radical surgery. The risk of development of a second malignant tumor with the administration of modern treatment appears to be minimal. There is an urgent need for better documentation of etiologic factors.
30岁以下患者头颈部恶性肿瘤较为罕见。我们组的生存率与患有相似肿瘤的成人患者的生存率相比更具优势，这支持了积极治疗的实施。在生长发育阶段进行放射治疗会抑制骨骼生长并导致组织萎缩，进而产生面部不对称，但与根治性手术相比，它在功能恢复方面能取得更好的平衡，且造成的毁容更少。采用现代治疗方法引发第二种恶性肿瘤的风险似乎极小。迫切需要更好地记录病因因素。
