Touloukian R J
J Pediatr Surg. 1978 Oct;13(6):468-74. doi: 10.1016/s0022-3468(78)80307-8.
Jejunoileal atresia without significant shortening of total intestinal length, was created in five date-bred Dorset ewes by devascularizing a 15 cm segment of fetal intestine at 90-100 days gestation. Light microscopy showed mucosal hypertrophy distal to the atresia with almost total obliteration of the lumen by tail, feathery-shaped villi similar to those observed in newborns with jejunal atresia. Scanning electron microscopic views of the proximal mucosa showed the villi to be thicker, more segmented and tended to congregate compared to normal villi and those distal to the atresia. No evidence of microvillus, intracellular or capillary membrane change or injury could be identified to explain the functional secretory state.
通过在妊娠90 - 100天时使15厘米长的胎儿肠段缺血，在五只日龄的多塞特母羊中造成空回肠闭锁，且总肠长度无明显缩短。光学显微镜检查显示闭锁远端的黏膜肥大，管腔几乎完全被尾状、羽毛状绒毛闭塞，类似于空肠闭锁新生儿中观察到的情况。近端黏膜的扫描电子显微镜观察显示，与正常绒毛和闭锁远端的绒毛相比，这些绒毛更厚、更有节段性且倾向于聚集。未发现微绒毛、细胞内或毛细血管膜变化或损伤的证据来解释功能分泌状态。
