Friedman H I, Villar H V, Nemeth T J
Surg Gynecol Obstet. 1981 Sep;153(3):346-50.
Twelve patients underwent a takedown of the jejunoileal bypass with restoration of normal continuity of the intestine. Specimens were obtained for biopsy from the excluded proximal jejunum and distal ileum as well as the distal in continuity jejunum. Hypertrophy of the mucosa was observed in the in continuity segment, as previously described. Villi of the bypassed jejunum displayed no evidence of hypertrophy or of atrophy and were identical in size to villous measurements prior to creation of the jejunoileal bypass. At the ultrastructural level, absorptive cells of bypassed jejunal segments exhibited normal morphologic characteristics. There was no indication of cellular immaturity above the level of the intestinal crypts. In contrast, villi of bypassed ileum, near the colonic anastomosis, demonstrated hypertrophy, presumably reflecting reflux of luminal material into this segment of bypassed intestine. The results of this investigation support the concept that significant morphologic alterations of the mucosa do not occur in totally bypassed segments of intestine after the jejunoileal bypass procedures with attainment of weight stabilization.
12例患者接受了空肠回肠旁路术的拆除，恢复了肠道的正常连续性。从被排除的近端空肠、远端回肠以及连续的空肠远端获取标本进行活检。如前所述，在连续段观察到黏膜肥大。旁路空肠的绒毛未显示肥大或萎缩的迹象，其大小与空肠回肠旁路术创建前的绒毛测量值相同。在超微结构水平上，旁路空肠段的吸收细胞表现出正常的形态特征。在肠隐窝水平以上没有细胞不成熟的迹象。相比之下，靠近结肠吻合口的旁路回肠绒毛显示肥大，推测这反映了管腔内物质反流到该段旁路肠中。这项研究的结果支持这样一种观点，即在空肠回肠旁路术实现体重稳定后，完全旁路的肠段不会发生黏膜的显著形态学改变。
