Egar M, Wallace H, Singer M
Anat Embryol (Berl). 1982;164(2):221-8. doi: 10.1007/BF00318506.
Partially innervated axolotl arms gave regenerates of reduced size with deficient skeletal element replacement. This deficiency was most pronounced when nerve 4 (the largest of the brachial nerves) estimated to make up 50-60% of forelimb axons was removed by repeated resection. Nerve 3 or 5 removal gave less pronounced reduction deformities in the newly formed regenerate. The dependency of skeletal element formation upon nerves is emphasized but does not follow a strict segmental subtraction in axolotl forelimbs--perhaps because of overlapping innervation of nerves 3, 4, and 5 to all four digits. These effects of partial innervation add tentative support for an hypothesis of neurotome subtraction that was proposed to account for the syndrome of thalidomide abnormalities.
部分神经支配的美西螈手臂再生出的肢体尺寸减小，骨骼元素替换不足。当通过反复切除去除估计占前肢轴突50 - 60%的第4神经（臂神经中最大的神经）时，这种不足最为明显。切除第3或第5神经后，新形成的再生肢体的畸形减少不太明显。骨骼元素形成对神经的依赖性得到强调，但在美西螈前肢中并不遵循严格的节段性减法——这可能是因为第3、4和5神经对所有四个指的神经支配重叠。部分神经支配的这些影响为为解释沙利度胺异常综合征而提出的神经节减法假说提供了初步支持。
