Wallace H, Watson A, Egar M
J Embryol Exp Morphol. 1981 Apr;62:1-11.
Forearms of juvenile axolotls contain about 5000 axons, of which only 25% are myelinated and visible by light microscopy. Virtually all the axons degenerate after transection of the brachial plexus, but repeated operations fail to keep the arm completely denervated. Regrown nerve fibres were detected by electron microscopy after 6 weeks of attempted denervation and related to the quantity usually considered necessary for limb regeneration. Such arms regenerated quite normally, provided their innervation had been depleted for several weeks before amputation. Among other ways of reconciling these observations to the neurotrophic theory of limb regeneration, it is suggested that tissues can adapt to deprivation of their nerve supply.
幼年蝾螈的前臂含有约5000条轴突，其中只有25%有髓鞘且在光学显微镜下可见。臂丛神经横断后，几乎所有轴突都会退化，但反复手术并不能使手臂完全去神经支配。在试图去神经支配6周后，通过电子显微镜检测到再生的神经纤维，并将其与肢体再生通常认为所需的数量相关联。如果在截肢前几周其神经支配已被耗尽，这样的手臂能正常再生。在将这些观察结果与肢体再生的神经营养理论相协调的其他方法中，有人提出组织可以适应神经供应的缺失。
