Jaben S L, Norton E W
Ann Ophthalmol. 1982 Aug;14(8):717-20.
We have presented a case of Wegener's granulomatosis with characteristic systemic and ocular manifestations. The diagnosis was determined pathologically by thoracotomy and lung biopsy. Our patient's ocular complications included an intense vitritis, exudative retinal detachment, choroiditis, and other corneoscleral manifestations. Exudative retinal detachment is a finding not previously described clinically, but alluded to in pathologic descriptions from case reports. Both systemic and ocular response were obtained within weeks after the patient started cyclophosphamide and prednisone. In addition to recording this new finding, we have reviewed the pathology and ocular manifestations of this uncommon disorder, outlined a modern therapeutic protocol, and updated the present-day prognosis of Wegener's granulomatosis.
我们报告了一例具有典型全身和眼部表现的韦格纳肉芽肿病。通过开胸手术和肺活检进行病理诊断。我们患者的眼部并发症包括严重的葡萄膜炎、渗出性视网膜脱离、脉络膜炎以及其他角膜巩膜表现。渗出性视网膜脱离是此前临床未描述过的表现，但在病例报告的病理描述中有提及。患者开始使用环磷酰胺和泼尼松治疗数周内，全身和眼部症状均得到缓解。除了记录这一新发现外，我们还回顾了这种罕见疾病的病理学和眼部表现，概述了现代治疗方案，并更新了韦格纳肉芽肿病的当前预后情况。
