Travis W D, Carpenter H A, Lie J T
Am J Surg Pathol. 1987 Sep;11(9):702-8.
We report two cases of Wegener's granulomatosis with the unusual manifestation of diffuse alveolar hemorrahge. One patient with well-documented Wegener's granulomatosis developed alveolar hemorrhage 4 weeks after leukopenia necessitated the discontinuation of cyclophosphamide. The second patient presented with pulmonary hemorrhage and died 10 days after an open-lung biopsy in which histologic features of Wegener's granulomatosis were overshadowed by alveolar hemorrhage. Lung biopsies in both cases showed marked alveolar hemorrhage and pulmonary capillaritis. The importance of recognizing capillaritis and other subtle histologic features of Wegener's granulomatosis are emphasized.
我们报告两例韦格纳肉芽肿病，均表现为罕见的弥漫性肺泡出血。一例韦格纳肉芽肿病确诊患者，在白细胞减少导致环磷酰胺停用4周后发生肺泡出血。第二例患者出现肺出血，在开胸肺活检10天后死亡，此次活检中韦格纳肉芽肿病的组织学特征被肺泡出血掩盖。两例患者的肺活检均显示明显的肺泡出血和肺毛细血管炎。强调了认识韦格纳肉芽肿病毛细血管炎及其他细微组织学特征的重要性。
