Wilhelm J L, Zakov Z N
Ann Ophthalmol. 1982 Aug;14(8):789-91, 794-6.
A case of a relatively small ocular malignant choroidal spindle B-type melanoma showed evidence of metastasis at the time of diagnosis of the initial primary tumor. We believe that, for two reasons, the true incidence of metastatic disease at the time of initial diagnosis of choroidal malignant melanoma is not known incomplete workup at the time of diagnosis, and the high percentage of false-negative results of common tests for detecting metastasis. We believe that all patients with the diagnosis of malignant melanoma should have at least a complete physical examination, liver function tests, liver--spleen scan, bone scan, and chest roentgenogram. If enucleation is performed, it should be done as atraumatically as possible. Some aspects of treatment are controversial. Unfortunately, not enough data regarding malignant melanoma or its metastasis are known to recommended with confidence the best method for treating either condition.
一例相对较小的眼部恶性脉络膜梭形B型黑色素瘤在原发性肿瘤初诊时就已出现转移迹象。我们认为，由于两个原因，脉络膜恶性黑色素瘤初诊时转移性疾病的真实发病率尚不清楚，一是诊断时检查不全面，二是检测转移的常见检查假阴性结果比例较高。我们认为，所有被诊断为恶性黑色素瘤的患者都应至少进行一次全面的体格检查、肝功能检查、肝脾扫描、骨扫描和胸部X光检查。如果进行眼球摘除术，应尽可能减少创伤。治疗的某些方面存在争议。不幸的是，关于恶性黑色素瘤或其转移的已知数据不足，无法有把握地推荐治疗这两种情况的最佳方法。
