Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Rd, Nangang District, Harbin, China.
Jpn J Clin Oncol. 2013 Mar;43(3):314-7. doi: 10.1093/jjco/hys229. Epub 2013 Jan 4.
Choroidal melanoma is the most common intraocular malignancy and can be fatal in half of the patients because of metastatic disease. Metastasis of choroidal melanoma to the omentum is extremely rare and, to our knowledge, no such case has ever been described in the literature. Here we present a 41-year-old Chinese man with an omental metastasis, 5 years after he was diagnosed with a spindle-cell-type malignant melanoma of the choroid and had his left eye enucleated. The patient demonstrated some uncommon symptoms, but the diagnosis was confirmed histopathologically. The cells were positive for S-100, HMB-45 and Melan-A proteins. He underwent a complete tumor resection and concomitantly received chemotherapy, biological treatment and traditional Chinese medicine. At 2-year follow-up, this patient continues to do well.
脉络膜黑色素瘤是最常见的眼内恶性肿瘤,约有一半的患者会因转移而死亡。脉络膜黑色素瘤转移至大网膜极其罕见,据我们所知,文献中尚无此类病例的描述。本文报道了 1 例脉络膜 spindle 细胞型恶性黑色素瘤患者,5 年前行左眼眼球摘除术,术后诊断为脉络膜黑色素瘤,术后 5 年发现大网膜转移。该患者表现出一些不常见的症状,但经组织病理学诊断明确。免疫组化结果显示:肿瘤细胞 S-100、HMB-45 和 Melan-A 蛋白阳性。该患者接受了大网膜肿瘤完整切除术,并同时接受了化疗、生物治疗和中医治疗。随访 2 年,患者病情稳定。